Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons
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چکیده
منابع مشابه
Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons
In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neuron, tau aggregates also spread to neighboring, recipient cells where the misfolded tau aggregates, in a manner similar to prions, actively corrupt the proper folding of soluble tau, and t...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2018
ISSN: 2051-5960
DOI: 10.1186/s40478-018-0514-4